As the world starts to reopen and we grapple with other, immediate global concerns, the virus's fate has only one outcome: it will become endemic in our society. Each major variant so far has been more transmissible than its predecessors and brings different symptoms and differing resistances and susceptibilities to vaccines or treatments. Resurgent waves of breakthrough infections, driven most recently by the Omicron variant, in vaccinated populations with waning immunity, remain an ongoing risk to economic recovery and healthcare.